Chapter 15

24 July 2022
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What type of tissue, present in the walls of blood vessels, allows for regulation of vessel diameter?
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Smooth muscle
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What maintains the driving pressure on blood while the heart is not contracting (ventricular diastole)?
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Recoil of the elastic arteries
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What compensatory mechanisms are available to help maintain blood pressure when a large volume of blood is lost, such as during a hemorrhage?
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Vasoconstriction, increased thirst, and decreased renal fluid output in the urine
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Which changes in paracrines cause vasodilation? What is the result?
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Decreased O2, increased CO2, increased H+, increased NO, result in increased blood flow.
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What does the total blood flow through ALL of the bodies arterioles equal?
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Cardiac output
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If there were a sudden increase in blood volume, what would the baroreceptors do and what would be the effect of that reflex?
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Increase firing rate; decrease contractility
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The lipid material of an atherosclerotic plaque accumulates
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deep to the tunica intima in the arterial wall
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Which set of changes correctly describes the baroreceptor reflex in response to increased blood pressure?
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Increased vessel diameter, decreased resistance, decreased cardiac output
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Which blood vessel layer secretes paracrine factors, which participate in the regulation of blood pressure and blood vessel growth?
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Endothelium
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White blood cells are generally too large to pass through capillaries. What route must they follow to move from the arterial to the venous circulation?
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Metarterioles
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Fainting is also known as
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vasovagal syncope
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Perfusion is
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blood flow through an organ
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are also known as the pressure reservoir of the cardiovascular system
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Arteries
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The inner lining of blood vessels is called
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endothelium
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Smooth muscle is present in the walls of
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all vessel types except capillaries.
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The highly branched contractile cells that regulate capillary permeability are called
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pericytes.
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Differences between arterioles and metarterioles include the fact that arterioles
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have a continuous smooth muscle layer in their walls.
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The only blood vessels whose walls permit exchange between the blood and the surrounding interstitial fluids are the
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venules and capillaries
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Angiogenesis is
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the growth of new blood vessels.
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Angiostatin and endostatin may be useful in the treatment of
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cancer.
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The endothelium of the blood vessels and its adjacent connective tissue make up the ________, which is surrounded by layers of smooth muscle and connective tissue called ________.
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tunica intima, tunica media
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Capillary walls consist of ________, supported on a cellular matrix called ________.
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endothelium, the basal lamina
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Cerebral capillaries are surrounded by ________ and glial cells and have tight junctions that create the ________.
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pericytes, blood-brain barrier
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Venules are similar to capillaries: they have ________ epithelium and only small amounts of ________.
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a thin exchange, connective tissue
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Loss of pericytes around retinal capillaries is a hallmark of the disease
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diabetic retinopathy.
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Blood pressure can be measured with a sphygmomanometer. When the display indicates diastolic pressure, what is heard through the stethoscope. Why?
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Nothing is heard because blood flow is smooth through the fully open artery.
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What is the role of the kidney in blood pressure regulation?
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The kidney can eliminate water to decrease blood volume or it can conserve water to maintain blood volume.
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Which is the correct relationship between pressure, flow, and resistance?
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Pressure ∝ Flow Γ— Resistance
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Mean arterial pressure is equal to diastolic pressure plus one-third of the pulse pressure. An equivalent equation is MAP = 2/3 DBP + 1/3 SBP. Why is diastolic blood pressure a larger component of MAP than systolic blood pressure?
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The heart spends more time in diastole than systole; therefore, the equation reflects the difference in time.
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Using a sphygmomanometer, a nurse measures a patient's blood pressure as 134/86. What is the patient's pulse pressure and mean arterial pressure?
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PP = 48 mm Hg and MAP = 102 mm Hg
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What effect would an increase in blood volume have on the resistance to blood flow?
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Nothing, they are not directly linked.
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What effect would an increase in venous tone have on mean arterial pressure?
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It would increase it by shifting blood from the veins into the arteries.
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The values obtained when measuring blood pressure, such as 120/80,
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reflect the pressure in the major arteries during ventricular systole and diastole.
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Which of the following is occurring during systole?
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blood pressure increases and more stress is placed on arterial walls
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The mean arterial pressure (MAP) is important because
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it represents the driving pressure for blood flow.
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Blood pressure is determined by
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measuring the force exerted by blood in a vessel.
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The difference between the systolic and diastolic pressures is called the
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pulse pressure
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All of the following would cause an increase in blood pressure EXCEPT
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a decrease in cardiac output.
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Which organ is NOT part of the cardiovascular system and plays an important role in regulating blood pressure?
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kidney
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Blood pressure is highest in the ________ and decreases continuously as blood flows through the circulatory system, due to ________.
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arteries, resistance from vessel walls
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The rapid pressure increase that occurs when the left ventricle pushes blood into the aorta can be felt as
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the pulse.
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Venous return to the heart is aided by the
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skeletal muscle pump and the repiratory pump.
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A rupture of a blood vessel in the brain is called a(n) ________ and may cause the loss of neurological function commonly called ________.
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cerebral hemorrhage, stroke
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Mean arterial pressure is ________ proportional to cardiac output and ________ proportional to resistance of arterioles.
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directly, directly
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The turbulent flow of blood causes a noise called a ________ that can be heard through the stethoscope when taking blood pressure.
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Korotkoff sound
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The structures that regulate blood flow into single capillaries within a tissue are
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precapillary sphincters.
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Which type of vessel changes most to regulate resistance to blood flow. Why?
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Arterioles because of the large amount of smooth muscle in their walls.
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What is the mechanism behind myogenic autoregulation in vascular smooth muscle?
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When cells stretch, mechanically gated cation channels open depolarizing the cell resulting in contraction
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What causes active hyperemia?
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Increased metabolism results in a local increase in CO2.
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Under what circumstance would the heart produce significant levels of adenosine?
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Myocardial hypoxia
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Which paracrine acts as a vasoconstrictor?
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Serotonin
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Blood flow to a tissue will increase if the
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level of carbon dioxide at the tissue increases
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The vessels that are the main site of variable resistance in the circulatory system, and that contribute more than 60% of the total resistance, are the
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arterioles.
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If cardiac output increases and resistance in arterioles does NOT change, what happens to arterial blood pressure?
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increases
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Increased blood volume ________ blood pressure.
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increases
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Myogenic autoregulation means that
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stretched smooth muscle in a blood vessel constricts reflexively.
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Each of the following paracrines may cause vasodilation EXCEPT
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Ca2+.
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Reactive hyperemia is
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increased blood flow following a period of reduced blood flow.
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Reactive hyperemia is triggered by
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local accumulation of paracrines due to reduced blood flow.
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The elevated blood pressure that sometimes accompanies pregnancy is known as
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preeclampsia
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In order to cause vasodilation of most vascular smooth muscle,
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sympathetic stimulation is removed
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Several blood-borne chemicals affect the lumen size of arterioles. Which are NOT paired correctly?
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serotonin vasodilation
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________ capillaries are very porous and allow high volumes of fluids to pass through them, whereas ________ capillaries consist of more tightly joined cells that allow a high degree of selective materials to pass.
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Fenestrated, continuous
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Sinusoids are modified vessels that replace ________ in some tissues.
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capillaries
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The integrating center for neural control of blood pressure resides in the
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medulla oblongata
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Stretch-sensitive mechanoreceptors known as ________ are located in some artery walls.
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baroreceptors
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When blood pressure is normal, the receptors in arterial walls fire action potentials
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continuously
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When blood pressure receptors sense a loss of blood pressure, they ________ their firing rate.
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decrease
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Blood pressure and cardiac output can be altered according to
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body temperature, emotional responses, and blood oxygen levels.
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When the baroreceptor reflex is triggered by a decline in blood pressure,
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sympathetic activity increases and cardiac output increases.
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If a person is bedridden for several days, the baroreceptor reflex may fail upon standing. Why?
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The kidneys have reduced the blood volume
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________ is an increase in blood flow that accompanies an increase in metabolic activity.
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Active hyperemia
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Norepinephrine binding to alpha receptors on vascular smooth muscle causes ________ and epinephrine binding to alpha receptors on vascular smooth muscle causes ________.
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vasoconstriction, vasoconstriction
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The decrease in blood pressure upon standing is known as
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orthostatic hypotension.
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The term for chronically elevated blood pressure is
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hypertension.
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Receptors that monitor blood pressure are called
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baroreceptors.
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Compensation for decreased blood volume includes increases in
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sympathetic stimulation to blood vessels, sympathetic stimulation of the heart, and water conservation by the kidneys.
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Fenestrated capillaries are present in
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the liver.
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Regarding the cardiovascular system, the main role(s) of the kidneys is/are to
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minimize fluid loss from the blood and therefore maintain blood pressure and reduce blood volume and therefore reduce blood pressure.
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Which of the following conditions would have the greatest effect on peripheral resistance?
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doubling the diameter of a vessel
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Each of the following factors would increase peripheral resistance except one. Identify the exception.
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vasodilation
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If a person has a blood pressure of 120/80, her mean arterial pressure would be
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93 mm Hg.
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The cardiovascular control center in the brain can directly cause
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arterioles to dilate or constrict and the heart rate to increase or decrease.
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Which of the following is greater?
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blood pressure when sympathetic stimulation to the heart increases
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Which of the following is greater?
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heart rate during circulatory shock
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Which of the following is greater?
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blood pressure when the peripheral vessels constrict
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Increased levels of carbon dioxide in the blood will result in
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decreased parasympathetic stimulation of the heart.
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During the fight-or-flight reaction, epinephrine is released from the adrenal medulla and binds to ________ receptors on the vascular smooth muscle of heart, liver, and skeletal muscle arterioles and results in ________ blood flow to these organs; epinephrine can also bind to ________ receptors on other tissues, causing ________ blood flow to these organs.
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Ξ²2, increased, Ξ±, decreased
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At rest, the majority of blood flows through the ________
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liver and digestive tract
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The matching of blood flow to the changing metabolic needs of a tissue is due to
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local control.
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The bone marrow, the liver, and the spleen do NOT have traditional capillaries. Instead, they have modified vessels called ________ that are ________ than a capillary.
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sinusoids, wider
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Blood velocity is lowest in the ________.
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capillaries
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What determines the blood flow through individual blood vessels in a local system of vessels?
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Resistance in each vessel
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Which syndrome is consistent with a big increase in parasympathetic activity leading to widespread vasodilation and fainting.
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Vasovagal syncope
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If a person's lymph vessels suddenly vanished (an impossible scenario), what impact would this have on the circulatory system?
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Blood volume and blood pressure would decrease
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Why is the velocity of blood lowest in the capillaries as compared to all other types of vessels?
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The capillaries have the largest cross sectional area.
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What is the mechanism by which bulk flow occurs at the capillaries?
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Relatively higher hydrostatic pressure on the arterial end of the capillary and relatively higher colloid oncotic pressure on the venous end results in net flow out of the capillary.
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Compared to arteries, the velocity of flow of the blood through the capillaries is
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much slower.
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Due to the differences in opposing forces, there is net ________ occurring at the arteriolar end of most capillaries, coupled with net ________ at the venous end.
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filtration, absorption
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Osmotic pressure resulting from presence of plasma proteins in blood is called ________ pressure.
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oncotic and colloid osmotic
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The osmotic pressure created by the presence of proteins is known as ________, which is _________ in the plasma than in the interstitial fluid.
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oncotic pressure, higher
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Capillary exchange involving movement between the endothelial cells is called the
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paracellular pathway.
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Capillary exchange involving movement through the cells is called ________ transport.
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endothelial
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Bulk flow refers to the mass movement of fluid between the blood and the interstitial fluid. Which of the following statements is not correct concerning bulk flow?
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In a typical capillary, overall bulk flow transitions from net absorption on the arterial end to net filtration on the venous end.
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Restoring lost fluid from the capillaries back to the circulatory system is one of the major functions of the ________ system.
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lymphatic
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A parasitic condition resulting in extreme enlargement of one or both legs is called
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elephantiasis.
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The accumulation of fluid in the interstitial space is called
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edema.
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The lymphatic system
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empties the lymph vessels into the veins near the clavicles.
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Malnutrition can cause edema because
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there are not enough nutrients for plasma protein synthesis.
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The continual movement of fluid through the interstitial space functions to
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All of the answers are correct
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Given that there is a baroreceptor reflex to regulate blood pressure, how is it possible for blood pressure to remain elevated in individuals diagnosed with chronic hypertension?
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Baroreceptors adapt to the higher blood pressure, down-regulating their response.
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Blood pressure and flow to the brain are monitored by receptors located in the wall of the
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carotid artery
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Which of these does NOT increase the risk for cardiovascular disease?
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being a female over 30 but under 55
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For a diagnosis of hypertension, a patient must have
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a systolic pressure above 140 mm Hg or a diastolic pressure above 90 mm Hg.
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Edema is likely to occur when
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the heart becomes an insufficient pump.
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Which of the following is/are (a) possible treatment(s) for hypertension?
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calcium channel blockers and ACE inhibitors
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Tom suffers from hypertension (high blood pressure). Which of the following might help deal with his problem? A drug that
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blocks beta receptors in cardiac muscle tissue.