PHYSIOEX

24 July 2022
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question
What is the equation of flow?
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Flow= pressure gradient/ resistance
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Blood flow
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The amount of blood moving through a body area or the entire cardiovascular system in a given amount of time.
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Total blood flow is proportional to cardiac output (the amount of blood the heart is able to pump per minute).
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TRUE
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Resistance
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A measure of the degree to which the blood vessel hinders, or resists, the flow of blood.
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What are the factors that affect resistance?
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Blood vessel radius Blood vessel length Blood viscosity
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The smaller the blood vessel radius, the greater the resistance?
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TRUE, because of the friction dragged between the blood and the vessel walls.
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Constriction, of smooth muscle of the blood vessel or vasoconstriction, results in a decrease in the blood vessel radius?
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TRUE, lipid deposits can also cause the radius of an artery to decrease, preventing blood from reaching the coronary tissue, which frequently leads to a heart attack.
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Relaxation of smooth muscle of the blood vessel (vasodilation) causes an increase in the blood vessel radius?
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TRUE
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The longer the vessel length , the greater the resistance?
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TRUE, because of the friction between the blood and vessel walls. The length of a person's blood vessel changes only as a person grows.
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Viscosity?
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Blood "thickness" determined primarily by hematocrit. The higher the hematocrit, the greater the viscosity.
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The viscosity of blood is due to the presence of plasma proteins and formed elements, which include?
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White blood cells (leukocytes), red blood cells (erythrocytes) and platelets (thrombocytes).
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Blood flow is __________ to blood pressure because the pressure difference between the two ends of a vessel is the driving force for blood flow.
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directly proportional
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The friction that opposes blood flow through a blood vessel?
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Peripheral resistance
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What are the three factors that contribute to peripheral resistance?
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Blood viscosity Blood vessel length Blood vessel radius
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The free-flowing blood in the middle of the vessel is?
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Laminar flow
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What are some factors that affect blood viscosity are
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Dehydration Blood cell count (e.g polycythemia)
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Blood vessels length increase as we grow to maturity?
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TRUE, the longer the vessel, the greater the resistance to blood flow through the blood vessels because there is a larger surface are in contact with the blood cells.
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When blood vessel length increases, friction increases?
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TRUE
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Gaining weight increases vessel length, losing weight decreases blood vessel length?
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TRUE
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When blood vessel length increases , friction __________
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Increases
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The pressure difference between the two ends of a blood vessel is the driving forces behind blood flow?
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TRUE, this pressure difference is referred to as a pressure gradient.
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The force of contraction of the heart provides the initial pressure an vascular resistance contribute to the pressure gradient?
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TRUE
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Large arteries close to the heart have more elastic tissue in their tunics in order to accommodate there changes?
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TRUE, if the heat changes its force of contraction, the blood vessel need to be able to respond to the changes in forces.
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The heart beats approximately ____ strokes each minute.
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70 Heart chambers fill during diastole (relaxation of the heart) and pump blood out during systole (contraction of the heart).
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The blood ejected by the heart _________
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Stroke volume The difference between the end diagnostic volume (EDV) and end systolic volume (ESV).
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Explain how the body establishes a pressure gradient for fluid flow?
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All fluids move from an area of higher fluid pressure to an area of lower fluid pressure. The blood vessel contract in one area and dilate in another area to direct blood flow.
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Explain the effect that the flow tube radius change had on flow rate?
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As the radius increases the flow will also increase. When radius decreases the flow decreases.
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Describe the effect that radius changes have on the laminar flow of a fluid?
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Increase blood vessel radius increases the laminar flow. Decrease in blood flow radius decreases the laminar flow.
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Why do you think the plot was not linear?
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The increase in blood radius resulted in a corresponding exponential increase in the rate of blood flow. Small increments in the radius resulted in larger increments in flow rate.
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Describe the components in the blood that affect viscosity?
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Presence of plasma proteins Formed elements (WBC's, RBC's & platelets)
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Explain the effect that the viscosity change had on flow rate?
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Increase viscosity decrease blood flow because of the blood thickness.
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Describe the graph of flow versus viscosity?
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As viscosity increase flow decrease
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Describe the effect that polycythemia would have on viscosity and on blood flow?
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Polycythemia is a condition in which excess red blood cells are present, and certain types of anemia result in fewer RBC's. Increasing the number of red blood cells increases blood viscosity, and decreasing the numbers of RBC's decreases blood viscosity.
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Which is more likely to occur, a change in blood vessel radius or a change in blood vessel length?
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Blood vessel radius is more likely to change because blood vessel length tends to stay pretty constant.
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Explain the effect that the changes in blood vessel length had on flow rate?
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The longer the vessel length, the greater the resistance, therefore increasing the vessel length decreases flow rate.
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Explain why you think blood vessel radius can have a larger effect on the body than changes in blood vessel length?
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Radius has a major effect because not can vasoconstrictor or vasodialate but also its multiply to the 4th power.
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Describe the effect that obesity would have on blood flow and why?
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Obesity would decrease blood flow because blood vessels length can increases when we weight is gain.
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Explain the effect that pressure changes had on flow rate?
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The body establishes a pressure gradient for fluid due to the pressure difference between the two ends of the vessels.
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How does the plot differ from the plots for tube radius, viscosity, and tube length?
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Its directly related relationship, as the pressure increases flow will also increase. As viscosity increases then flow will decrease and if length of vessel increases flow decreases, if radius increase flow increases as well.
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Explain why pressure changes are not the best way to control blood flow?
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Diameter changes are easier for the body to change, pressure changes require the heart to be able to respond to a different force. In the cardiovascular system, the force of contraction of the heart provides the initial pressure and vascular resistance contributes the pressure gradient. If the heart changes its force of contraction, the blood vessel need to be able to respond to the change in force.
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Describe how the frog heart and human heart differ anatomically?
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The frog heart has a single fused ventricle and we humans have 2 separate ventricles.
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Describe how stimulation of the vagus nerves affect the heart rate?
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The higher the vagus nerve activity results in lower heart rate (negative chronotropic effect).
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How does the sympathetic nervous system affect heart rate and the force of contraction?
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Sympathetic nervous system increases heart rate.
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Describe the mechanism of vagal escape?
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Too much vagal stimulation will essentially stop the heart, sometimes the sympathetic system encounters the changes and tries to compensate for the effect but sometimes its too late. The resumption of the heartbeat is referred to as vagal escape and can result of sympathetic reflexes or initiation of a rhythm by the parking fibers.
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What would happen to the heart if the vagus nerve were cut?
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It would increase heart rate and increate to100bpm
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Sympathetic system
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Flight or Fright Sympathetic nerve fibers release Norepinephrine(noradrenaline) and Epinephrine (Adrenaline).
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Norepinephrine & Epinephrine
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Increase the frequency of action potentials by binding to B1 adregenic receptor at the sinoatrial (SA) node.
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Parasympathetic nervous system
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Resting & Digesting Nerve fibers release Acetylcholine at their cardiac synapses.
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Acetylcholine (ACh)
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Decreases the frequency of action potentials by binding to muscarinic cholinergic receptors at the SA node cell.
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Acetylcholine
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Indirectly opens potassium channels and closes calcium and sodium channels, decreasing the rate of depolarization and thus, decreasing heart rate.
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Inhibits, mimics, or enhance the action of acetylcholine in the body is
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cholinergic
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Inhibits, mimics, or enhances the action of epinephrine in the body is
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Adregernic
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Epinephrine
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Increase heart rate 79BPM
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Atropine
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Increases heart rate 70BPM
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Digitalis
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Decreases heart rate 41 BPM
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Pilocarpine
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Decreases heart rate 45 BPM
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Explain why the larger wave seen on the oscilloscope represent ventricular contraction?
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The ventricle contraction is of greater force than the atrial contraction, this is due to the fact that ventricles function is to send blood throughout the body.
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Explain why the amplitude of the wave did not change when you increase the frequency of the stimulation?
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Amplitude does not change because the heart has long refractory period which prevents summation.
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Why is it only possible to induce an extrasystole during relaxation?
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The extrasystole cannot occur until relaxation and so we could not achieve wave summation tetanus.
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Explain why wave summation and tetanus are not possible in cardiac muscle tissue?
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Cardiac cells have a longer action potential sf twitches than any other muscle cells therefore Do Not show temporal summation.
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Explain two ways that the heart can overcome excessive vagal stimulation?
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Through the sympathetic reflex and the initiation of rhythm by the Purkinji Fibers.
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Describe the benefits of administrating digitalis?
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It increases the force of contraction while it decreases heart rate, increases stroke volume, slows Na+ pump.