Which of the following is not a protective feature in the central nervous system?
presence of the blood-brain barrier
presence of resident microbiota
presence of microglial cells
none of the above (all are protective features found in the CNS)
answer
presence of resident microbiota
question
Among the following organisms which can cause meningitis, which can be acquired through ingestion (contaminated poultry, meat, soft cheeses)?
Steptococcus pneumoniae
Listeria monocytogenes
Haemophilus influenza
Neisseria menigitidis
Streptococcus agalactiae
answer
Listeria monocytogenes
question
All of the following pertain to Neisseria meningitidis except:
Virulence factors include a capsule, pili, endotoxin and IgA protease
Causes a serious meningitis
Reservoir is the nasopharynx of human carriers (NOT)
More easily transmitted in daycare facilities, dorms and military barracks
Most common cause of bacterial meningitis in adults
answer
Most common cause of bacterial meningitis in adults
question
An oxidase-positive, Gram-negative diplococcus that causes meningitis is _____.
Escherichia coli
Streptococcus pneumoniae
Haemophilus influenzae
Neisseria meningitidis
Listeria monocytogenes
answer
Neisseria meningitidis
question
Reye's Syndrome is involvement of central nervous system symptoms after the interaction of a recent viral infection in a young person and ingestion of
penicillin.
alcohol.
acetaminophen.
salicylates (aspirin).
answer
salicylates (aspirin).
question
Which of the following is a fungal cause of meningitis?
Clostridium botulinum
Streptococcus agalactiae
Cryptococcus neoformans
Listeria monocytogenes
Haemophilus influenzae
answer
Cryptococcus neoformans
question
Indicate all the CNS infections for which vaccines exist.
Haemophilus influenza
Streptococcus pneumoniae
Neisseria meningitidis
Streptococcus agalactiae
Cryptococcus neoformans
Which of the following is a sign/symptom of meningitis?
headache
nausea/vomiting
stiff-neck
fever
all of the above are symptoms of meningitis
answer
all of the above are symptoms of meningitis
question
The presence of Gram positive diplococci and PMNs in the CSF of a suspected meningitis patient is indicative of:
aseptic meningitis
Cryptococcus meningitis
Neisseria meningitis
Streptococcal meningitis
All of the above
answer
Streptococcal meningitis
question
Meningococcemia is:
Best treated with Penicillin G
Associated with vascular collapse, hemorrhage and petechiae
Started from a nasopharyngeal infection
Caused by a Gram negative diplococcus
All the above are correct
answer
All the above are correct
question
Which of the following drugs could possibly be used to treat viral meningitis?
penicillin (NOT)
erythromycin
acyclovir
amphotericin B
neomycin
answer
acyclovir
question
What is a common virulence feature among several bacteria and fungi which can cause meningitis?
presence of fimbriae
presence of a capsule
presence of flagella (NOT)
production of A-B toxins (NOT)
all of the above (NOT)
answer
presence of a capsule
question
When traveling in the southwest U.S., what potential fungal respiratory pathogen could you be exposed to by inhaling spores present in the dust?
answer
coccidioides immitis
question
Which of the following neurological diseases is not caused by prions?
St. Louis encephalitis
Kuru
Creutzfeldt-Jakob disease
Scrapie
Bovine Spongiform encephalitis
answer
St. Louis encephalitis
question
Meningitis and encephalitis can be caused by which types of organisms?
viruses
bacteria
fungi
protozoa
all of the above
answer
all of the above
question
What types of infections are generally caused by insect-borne arborviruses? (answer all in lower case letters)
answer
acute encephalitis
question
Which of the following is not caused by an arbovirus?
St. Louis encephalitis
Eastern equine encephalitis
West Nile encephalitis
Herpes encephalitis
La Crosse encephalitis
answer
Herpes encephalitis
question
Although they may include symptoms associated with meningitis, patients with encephalitis may exhibit:
personality changes
confusion
memory loss
seizures
coma
all of the above
answer
all of the above
question
Most patients infected with an arborvirus associated with encephalitis exhibit:
prodromal illness
headache and seizures
no symptoms
coma (NOT)
answer
no symptoms
question
The production of a neurotoxin that binds to target sites on spinal cord neurons responsible for inhibiting skeletal muscle contraction is a characteristic of:
Clostridium botulinum
Clostridium perfringens
Clostridium difficile
Clostridium tetani
Bacillus antracis
answer
Clostridium tetani
question
The toxins produced in tetanus and botulism are examples of which type of toxin?
superantigens
endotoxins
hemolysins
A-B toxins
None of the above
answer
A-B toxins
question
Which of the following is incorrect/false, pertaining to Poliovirus infection?
Summer outbreaks in the U.S. have been recently increasing
Transmitted primarily by fecal contaminated water
Can be asymptomatic or mild with headache, sore throat, fever and nausea
If virus enters the central nervous system, motor neurons can be infected and destroyed.
Caused by Poliovirus (genus Enterovirus)
answer
Summer outbreaks in the U.S. have been recently increasing
question
Choose all the true statements regarding Rabies.
It is widespread in wildlife.
Vaccines are available to protect humans and domestic animals.
Hydrophobia is a characteristic symptom.
Human disease is predominantly associated with raccoon bites.
The incubation period from infection to neurological symptoms is 7-14 days.
answer
It is widespread in wildlife.
Vaccines are available to protect humans and domestic animals.
Hydrophobia is a characteristic symptom.
question
What food should you avoid feeding a child under 1 year old because of potential botulism?
Honey
Milk
Apple juice
Rice cereal
Applesauce
Botulism is caused by toxin production by _____.
A persistent virus
A fungal infection
An obligate anaerobe
A protist
An aerobic bacterium (NOT)
answer
An obligate anaerobe
question
Tetnus differs from botulism in that:
Tetanus results in flaccid paralysis while botulism paralysis is rigid
Tetanus results from an exotoxin, botulism from an endotoxin
There is a vaccine for botulism but not for tetanus
Tetanus results from exotoxin production within the body, whereas foodborn botulism results from exotoxin production outside the body
All the choices are true
answer
Tetanus results from exotoxin production within the body, whereas foodborn botulism results from exotoxin production outside the body
question
Which poliovirus vaccine is currently used in the United States?
Jenner vaccine
Salk vaccine
Sabin vaccine
MMR vaccine
None of the above
answer
Salk vaccine
question
The Sabin (attenuated) vaccine is no longer routinely used in the U.S. because:
Polio is no longer endemic in the U.S.
The Sabin vaccine has a risk of reversion to virulent form
Attenuated vaccines should not be used in the immunocompromised or pregnant.
All of the above
answer
All of the above
question
Which of the following pertains to both tetanus and food borne botulism?
Occurs when spore-contaminated soil enters deep wounds
Caused by enterotoxins of the pathogen
Exotoxin blocks acetylcholine release (NOT)
Nausea and diarrhea are symptoms
Treatment involves antitoxin therapy
answer
Treatment involves antitoxin therapy
question
Infections (meningoencephalitis) with the amoebas, Naegleria fowleri and Acanthamoeba are ..... (Indicate all the correct answers)
environmental
fatal
common
transmissible
answer
environmental & fatal??
question
The currently preferred preventative measure for polio in the United States is:
An attenuated vaccine developed by Louis Pasteur.
Passive immunotherapy with Polio-reactive antibodies
A polio, anti-toxin vaccine
Oral attenuated vaccine developed by Albert Sabin
Inactive vaccine developed by Jonas Salk
answer
Inactive vaccine developed by Jonas Salk
question
Which fungal organism is associated with bird droppings and can result in a meningitis following a respiratory infection?
answer
Cryptococcus neoformans
question
Polio is transmitted by _____.
Respiratory routes
Insect bites
Animal bite
Oral ingestion
answer
Oral ingestion
question
Which of the following organisms does not cause meningitis?
Streptococcus pneumoniae
Haemophilus influenzae
Streptococcus agalactiae
Clostridium botulinum
Neisseria meningitidis
answer
Clostridium botulinum
question
All of the following pertain to Neisseria meningitidis except:
Common cause of bacterial pneumonia
Reservoir is the nasopharynx of human carriers
Virulence factors include a capsule, pili, endotoxin and IgA protease
Causes a serious meningitis
More easily transmitted in daycare facilities, dorms and military barracks
answer
Common cause of bacterial pneumonia
question
Which of the following diseases is transmitted by an animal bite?
Tetanus
Rabies
Scrapie
Cryptococcus meningitis
Botulism
answer
Rabies
question
Among the following organisms which can cause meningitis, which can be acquired through ingestion (contaminated food)?
Steptococcus pneumoniae
Listeria monocytogenes
Neisseria menigitidis
Haemophilus influenza
Streptococcus agalactiae
answer
Listeria monocytogenes
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