Chapter 3 Compartmentation: Cells And Tissues

25 July 2022
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Metastasis
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When cancer debelops in one tissue and spreads to another via the blood or the lymph, the cancer is said to have undergone what process?
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The Lumen
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The space that is surrounded by the tissue wall of hollow organs is known as
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External
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The lumen of a hollow organ such as the stomach is considered to be part of the ___ environment
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Extracellular fluid
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The watery meduim that surrounds a cell is known as
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cell membrane, plasma membrane, plasmalemma
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All define the structures that separates the contencts of a human cell from its surrounding medium
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Bind to ligands, regulate the passage of ions, act as transport molecules for various solutes, anchor or stabilize the cell membrane
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Functions of membrane proteins
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Selectively permeable
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Cell membranes are said to be
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The formation of a barrier that is selectively permeable to lipid-soluble molecules and to provide a framework for membrane proteins
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The major roles of the phospholipid bilayer
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Sphingolipids, cholesterol, phospholipids
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Membrane lipids
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Plasma membrane
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Cellular organelle that is a lipid bilayer that controls which objects can leave or enter the cell
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An additive to creams and lotions and a drug-delivery vehicle
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A liposome is
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Can recognize cancer cells
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An immunoliposome is a liposome that
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Intermediate filaments
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Provide the cell with strength Stabilize the position of organelles Transport materials within the cytoplasm Form the neurofilaments in nerve cells
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Golgi complex
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The cellular organelle responisble for packaging and transporting proteins
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Cilia, centriole, ribosome, cytoskeleton
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Nonmembranous organelles
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Microtubules
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The thickest protein fibers
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Nucleoli
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Ribosomal RNA is formed by
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Mitochondria
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The mitochondrial cristae increase the inner surface area of the organelle. The matrix of the mitochondria contains metabolic enzymes involved in energy production. The mitochondria produce most of a cell's ATP.
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Sperm
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Only cell in humans with flagella
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Lysosomes
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Tay-Sachs is a disease casued by having ineffective
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in cells that are actively engaged in absorption
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Microvilli are found in
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Microtubules
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Are composed of tubulin, Are hollow filamentous structures, Form cilia that aid in cell movement, Are the largest cytoplasmic fibers
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Centrioles
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Direct the movement of DNA during cell division
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Mitochondria
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Produces most of the ATP required to power cellular operation
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Major functions of both types of ER are:
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Synthesis of biomolecules Transport of biomolecules Storage of biomolecules
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Proteins, fatty acids, steroids, and phospholipids
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Are synthesized along various sites of the endoplasmic reticulum
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Fatty acids, steroids, and lipids
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Are synthesized in the smooth ER
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Rough endoplasmic reticulum
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Consists of a network of intracellular membranes with attached ribosomes
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Lysosomes, peroxisomes, secretory vesicles, storage vesicles
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All are structures involved in storage
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Golgi complex for packaging
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The proteins synthesized in the rough ER are then sent to
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Digest cellular wastes and bacteria
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If a cell lacked lysosomes, it would not be able to
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Acid
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Which substance is responsible for activating the digestive enzymes inside lysosomes?
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Peroxisomes
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Use and enzyme to destroy H2O2 that is toxic to the cell.
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Greater than
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The number of mitochondria in skeletal muscle cells is ___ adipose (fat) cells
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Nucleus
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The control center for cellular operations is the
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Ribosomes
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The beta cells of the pancreas produce insulin, a protein-based hormone. Which of the following organelles would be found in higher levels in the beta cells?
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Smooth endoplasmic reticulum
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If the adrenal cortex produces lipid based hormones such as aldosterone, which organelle would be higher in cells of the adrenal cortex than in the adrenal medulla?
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Carbs, lipids, proteins, phospholipids
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The nucleus stores all the info needed to synthesize:
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Secretion
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The process by which a cell releases a substance into the extracellular space for a particular use
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Mitochondria
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Cellular organelle that is considered the powerhouse of the cell
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Protein secretion
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1. The polypeptide chain enters the lumen of the ER 2. A transport vesicle is formed 3. The polypeptide chain enters the lumen of the Golgi complex 4. A secretory vesicle is formed
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Paracellular
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Movements of material between cells
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Types of cell junctions
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Desmosomes, tight junctions, gap junctions, adherens junctions
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Stratified squamous epithelium
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The type of epithelium lining the esophagus
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Connexin
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The type of protein found in gap juntions
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Anchoring
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Disappearance of which type of junction most likely contributes to the metastasis of cancer cells throughtout the body?
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CAMs
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The types of junctions proteins important in growth and development
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Primary tissue types
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Muscle, neural, osseous, epithelial
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Functions of the epithelia
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Provideing physical protection, controlling permeability, producing specialized secretions, movement
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Microvilli
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Epithelial cells that are adapted for membrane transport of materials, such as ions and nutrients, usually have ___ on their apical surface.
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A basement membrane, protein filaments embedded in glycoprotein, and a basal lamina
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Epithelia are connected to underlying connective tissues by
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Endocrine glands
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Glands that secrete hormones into the blood via tissue fluids
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Exocrine glands
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May make either mucous or serous secretions, release their secretions into the external environment, release their secretions through open tubes called ducts, may work as single cells or as a multicellular organ
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True
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Every substance that enters or leaves the internal environment of the body must cross an epithelium
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True
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Due to the fact that they divide frequently, epithelia are prone to the genetic mutations associated with cancer
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Increase the cells surface area
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The function of microvilli, often seen on the apical membrane of transporting epithelia is to
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Endothelium
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The simple squamous epithelial lining of blood vessels
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Epithelial, neural, and muscle
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Tissue with minimal extracellular matrix
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Functions of connective tissue
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Establishing a structural framework for the body, transporting fluids and dissolved materials, providing protection for delicate organs, storing energy reserves
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Adipocytes
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Cells that store fat
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Loose connective tissue functions in
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Supporting small glands, supporting epithelia, anchoring blood vessels and nerves
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Plasma
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Is found within the circulatroy system, the fluid portion of blood, a subdivision of the ECF, sometimes donated instead of blood
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Apoptosis
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Programmed cell death
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Stem cells
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The term meaning a mitotic population of cells that persists into adulthood applies to
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Organs
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Groups of tissues that carry out related functions may
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Skin
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The heaviest organ in the body is the
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Mitochondria
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The powerhouse of the cell, ATP is produced here
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Peroxisomes
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These degrade long chain fatty acids and toxic foreign molecules
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Lysosomes
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It is the digestive system of a cell, degrading and/or recycling bacterial or organic components
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Golgi apparatus
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It modifies proteins andn packages them into secretory vesicles for export from the cell
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Gap junction
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Simplest cell-cell junction
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Tight junction
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Contributes to the blood-brain barrier
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Anchoring junction
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Can be cell-matrix junctions
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Anchoring junction
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Their loss is characteristic of cancer
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Fat
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Adipocyte
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Loose connective tissue
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Fibroblast
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Chondrocyte
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Cartilage
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Osteocyte
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Maintains bone matrix
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Osteoclast
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Destroys bone matrix
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Ribosome/ RNA
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Nucleoli function in the production of__
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Selective permeable
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Cell membranes are said to be __ because they allow some substances to pass but not others
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Nuclear envelope
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The nucleus is surrounded by a
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Nuclear pore
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Communication between the nucleus and cytosol occurs through
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Differentiation
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Cells are transformed into specialized units during
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Endothelium
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The lining of the heart and blood vessels is
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Matrix
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Is the extracellular component of connective tissues
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Extracellular matrix
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The combination of fibers and ground substance in supporting connective tissues
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Plasma
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The fluid substance of blood is
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Histology
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The study of tissue structure and function is called
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Glands
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Structures composed of epithelial cells that produce secretions
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Nervous tissue
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a tissue that is modified to transmit electrical signals from one cell to another
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Exocrine
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__ secretionsare discharged onto an epithelial surface
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Endocrine
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___ secretions are released into interstitial space to diffuse into the blood
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Trans-membrane
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__ proteins extend all the way across the cell membrane
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Peripheral
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__ proteins attach loosely to other membrane proteins or polar regions of phospholipids
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Glycocalyx
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__ is a protective layer made up of mostly membrane carbohydrates
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Undergo nuclear division
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If an animal cell lacked centrioles, it would not be able to
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Microtubles
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Which of the following cytoskeleton components are responsible for the movement of chromosomes during cell division
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Cilia
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A flagellum moves a cell through a fluid medium. What moves the fluid medium across the surface of cells that are not free to move
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Mitochondria
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The outer mitochondrial membrane is responsible for its shape, The intermembrane space is used in the production of ATP, Mitochondria are responsible for providing energy to the cell
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Cytosol
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Plasma is to blood as ___ is to cytoplasm
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Steroid hormones
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Examination of a sample of glandular cells reveals an extensive network of smooth endoplasmic reticulum. Which of the following would be a likely product of these cells?
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Rough endoplasmic reticulum
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In a pancreatic cell producting digestive enzyme, you would expect to find an elaborate
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Bone
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Chondrocytes are to cartilage as osteocytes are to
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Muscle tissue and neural tissue
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The tissues that are considered excitable because of the ability to generate electrical signals are called
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The esophagus because it is a passageway that needs to move but not absorb food products
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You are looking at a slide of an unknown organ that has an empty lumen with strasified squamous epithelium contacting the lumen. Deep to the epithelium is a basement membrane and then two layers of smooth muscle. Which of the following organs would this most likely belong to and why?
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Distinguishing characteristic of connective tissue is
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The presence of extensive extracellular matrix containing widely scattered cells
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Cartilage, bone, blood, dense
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Connective tissue with the typical characteristic regarding relative cell density
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Centrioles
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Mature nerve and muscle cells are expected to lack which organelle?
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Membranous organelle
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Lysosome, mitochondrion, endoplasmic reticulum
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Inclusion
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Ribosome, cilium
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Protective
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Found in the epidermis, esophagus, and mouth, these stacked layers of cells prevent exchange, while they resist chemicals, bacteria, and other destructive forces
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Transport
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This tissue actively and selectively regulates the exchange of nongaseous material, such as ions and nutrients, and can be regulated in response to various stimuli
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Exchange
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These thin, flattened cells allow the rapid passage of O2 and CO2 through the cells of the lungs and of certain blood vessels
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Secretory
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These cells produce a substance and release it, either onto a surface or directly into the blood
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Ciliated
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This tissue is composed of cells with membrane extensions that beat in a coordinated fashion to move fluid and particles across the tissue
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Function of Cell Membrane
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physical isolation regulation of exchange with the environment communication between the cell and its environment structural support
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Fluid Mosaic Model
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cell membrane is not static or uniform; things move around and have different compositions
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Phospholipid
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glycerol/phosphate head and fatty acid tails
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Sphingolipid
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phospholipid or glycolipid head and slightly longer fatty acid tails
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Micelle
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droplets of phospholipids
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Liposomes
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micelle with aqueous center
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Integral Proteins
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tightly bound to the membrane transmembrane --> extend all the way across the membrane lipid-anchored-->attached to lipid tails that are inserted into the bilayer
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Peripheral Proteins
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attached to other membrane proteins
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Glycoprotein & Glycolipid
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functions: structural stability cell recognition immune response
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Cholesterol
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keeps membrane flexible and impermeable to water soluble molecules
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Proteoglycans
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protein and carbohydrate
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Insoluble protein fibers
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function by giving cell strength and anchor cells to matrix for communication ex: collagen, fibronectin, & laminin
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Gap Junction
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communicating junction membrane protein --> connexin
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Occluding Junction
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tight junction membrane protein --> claudin and occludin
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Anchoring Junction
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support junction which holds cell in place Types of anchoring junctions: cell-cell junctions cell-matrix junctions
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Cell-Cell Anchoring Junction
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adherens junction & desmosome membrane protein --> caherin
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Cell-Maxtrix Anchoring Junction
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focal adhesion & hemi-desmosome membrane protein --> integrin
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Epithelial Tissue
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protection and regulate exchange lining body surfaces & secretory epithelia
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Connective Tissue
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structural support; sometimes physical barriers
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Muscle Tissue
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excitable, ability to contract and produce force
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Neural Tissue
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excitable, carry information in the form of electrical and chemical signals
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Basal lamina
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acellular matrix layer that is secreted by epithelial cells
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Classifications of Epithelial Tissue
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layering --> simple or stratified shape --> squamous, cuboidal, or columnar function --> exchange, transporting, ciliated, protective, and secretory
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Endothelium Tissue
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lines the circulatory system
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Transporting Epithelium
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cuboidal/columnar shape apical membrane (towards lumen) and basolateral membrane (ECM) tight junctions lots of mitochondria
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Ciliated Epithelium
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move fluid and particles in respiratory system and female reproductive tract
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Protective Epithelium
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stratified tissues that are toughened and found in areas of mechanical/chemical stress
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Secretory Epithelium
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grouped into gland; function include exocrine and endocrine
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Exocrine Secretions
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serous --> watery (tears and sweat) mucous --> produced by goblet cells