Chapter 6 Mastering A & P

25 July 2022
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question
Which form of cell-to-cell communication uses the direct transfer of electrical and chemical signals?
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Gap-junction signaling
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What determines which cell acts as targets for endocrine signals?
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those cells with receptors specific for signaling molecule.
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Art diagram figure 6.3 * identify features of cell signaling and receptors. also see (4-7)
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* Intracellular signal receptors, slower responses related to changes in gene activity. * Cell membrane receptors, rapid cellular response.
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Receptor channel
Receptor channel
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Ligand binding opens or closes the channel
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Receptor-enzyme
Receptor-enzyme
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Ligand binding to a receptor-enzyme activates an intracellular enzyme
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G-protein coupled receptor
G-protein coupled receptor
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A receptor that couples to G proteins, which bind to the guanine nucleotides GTP and GDP
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Integrin receptor
Integrin receptor
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Ligand binding to integrin receptors alters enzymes or the cytoskeleton
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Which specific characteristic must a signaling molecule have in order to bind to a cytosolic or nuclear receptor?
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It must be lipophilic.
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The binding of a single ligand to its receptor can activate many second messengers. Which characteristic of signal transduction systems is this?
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Signal amplification.
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Administration of ibuprofen can decrease pain. Why does this COX inhibitor have this effect?
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It blocks production of prostaglandins.
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A ___________ senses changes in physiological variables. (* Part A is #s 8-13)
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Sensor
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An ___________changes physiological variables in order to restore and maintain homeostasis.
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effector
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An ___________ synthesizes information coming in from many sensory pathways and sends out the proper response.
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integrating center
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A___________ results from changes in organ activity. It can cause a change in the original stimulus
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response
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An ____________ delivers information about environmental stimuli from the periphery to the control center.
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input signal
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An ____________ will deliver a chemical that will affect the target organ/effector. It can be carried out by a neuron, or a classic hormone released into the blood.
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output signal
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Simple & Complex Reflex Pathways
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Stimulus-->Sensor-->Afferent signal-->Integrating center-->Efferent signal-->Effector-->Response
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Describe the function of an afferent neuron.
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to deliver information about the physiological variable to the integrating center.
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Sequence of events in Simple Neural Pathway.
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Stimulus activates sensor----> Signal travels along a afferent neuron----> Spinal cord integrates and interprets signal----> Signal travels along an efferent neuron----> Signal arrives at the target tissues.
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A simple endocrine pathway will include which of the following?
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Classic hormone, circulatory system, target tissue, sensor, endocrine organ.
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Which is the best way to describe the role of the endocrine organs in both simple and complex reflex pathways?
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to function as a sensor and integrating center.
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Specialized neurons in the brain respond to changes in blood osmolarity (solute concentration). When blood osmolarity strays outside the homeostatic range, these neurons release a neurotransmitter that stimulates neurons of the posterior pituitary, which respond by releasing a different chemical into the blood that will travel via the circulatory system to the kidneys. How would you classify this type of simple reflex?
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neurohormone
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In order to prevent damage due to overstretching skeletal muscles contain specialized sensors. As a muscle stretches, information from these sensors is sent via afferent neurons to the spinal cord where the information is integrated. After integration is complete, an output signal is sent via efferent neurons to the muscle, preventing it from being stretched further. This is an example of what type of reflex pathway?
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simple neural
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Place the events associated with a Complex neuroendocrine pathway in the correct sequential order. (using phrases regarding the Gastrointestinal coordination of protein digestion to put together a complex neuroendocrine reflex pathway in the correct sequential order.) (*Rank from earliest to latest.)
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* Meal containing protein enters the stomach---> * Afferent neurons send information to nervous system in the gut lining.--> * Efferent neurons stimulate the G cell--> * G cell releases Gastrin in to the circulation.--> * Gastrin stimulates the parietal cell.--> * Parietal cell release hydrochloric acid
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Using the scenario in part 1, what is the role of the Gastrin-producing G cell in the neuroendocrine pathway?
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second integrating center.
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In the sequence of events mapped out in part 1, what is the response? (*found 8-13)
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release of hydrocholric acid by the parietal cell.
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A given hormone affects____________.
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only specific target cells, because nontarget cells lack the appropriate receptors.
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Choose a true statement.
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a) neurotransmitters are a type of neurohormone. b) paracine signals are used for long-distance communication. c) Autocrine signals are produced by and act upon the same cell. d) Cytokines are generally made in advance and stored until needed. *C
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Correct example of a signal amplification.
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One hormone molecule causes the activation of more than one second messenger molecule.
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Which type of receptor alters the cytoskeleton when its ligand binds to it?
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Integrin receptor.
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Ion channels can be opened or closed via three signal transduction mechanisms. Two of them are extracellular signals and second messengers. What is the 3rd mechanism for opening or closing ion channels?
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G protein action
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The ion that controls the widest variety of intracellular activities is _______________.
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calcium
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Signal molecules that degrade most rapidly, resulting in very brief effects, are_____________.
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gases such as nitric oxide
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Which is the best example of a second messenger?
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Intracellular Ca 2+
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Which of the following is the most accurate definition of Homeostatis?
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the ability of an organism to maintain relatively constant internal conditions despite variability in external conditions.
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What is the best definition of "homeostasis"?
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the ability of living systems to maintain a relatively constant internal environment.
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Which term best describes the component of a control system that receives information about the status of a homeostatically regulated variable and initiates an appropriate response?
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integrating center
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Heating an area of the skin can cause sweat glands in that area to begin producing and releasing sweat. This is an example of what type of control system?
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local control system
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Examples of homeostatic regulation: 1) In response to an increase in plasma K+ concentrations, secretion of the hormone aldosterone increases and mechanisms that bring K+ levels back to normal are initiated. 2) In response to a decrease in plasma Ca2+ concentrations, secretion of parathyroid hormone increases and mechanisms that bring Ca2+ levels back to normal are initiated. Which of the statements are true?
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Both are examples of a negative feedback regulation.
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In response to the presence of glucose in the stomach, mechanisms are set in motion resulting in release of insulin, which acts to increase glucose uptake and thus decrease blood glucose. This happens before blood glucose levels have increased. This response is best describes as_____________.
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feedforward control.
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Negative feedback in reflex loops___________.
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is common because it promotes homeostasis.
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Compared to endocrine reflexes, neural reflexes_____________.
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respond rapidly, and are very brief.
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The hypothalamus senses the temperature of the blood via thermoreceptors. When blood temperature begins to drop, the hypothalamus releases a hormone, TRH, that stimulates the release of TSH from the anterior pituitary gland to release thyroid hormone (TH). TH causes a increase in body temperature, which causes the Hypothalamus to stop releasing TRH. In this reflex pathway, what is the response?
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Increased body temperature.
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The hypothalamus senses the temperature of the blood via thermoreceptors. When blood temperature begins to drop, the hypothalamus releases a hormone, TRH, that stimulates the release of TSH from the anterior pituitary gland. TSH causes the thyroid gland to releases thyroid hormone (TH). TH causes a increase in body temperature, which causes the Hypothalamus to stop releasing TRH. Which type of reflex pathway is this thermoregulatory pathway?
answer
Complex neuroendocrine reflex