Lab #6

25 July 2022
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Depolarize
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The membrane potential is becoming more positive than the resting membrane potential
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Repolarize
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The membrane potential is moving from a more positive value toward resting membrane potential
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Hyperpolarize
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The membrane potential is more negative than the resting membrane potential
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voltage-gated channels
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Action potentials are due to which type of ion channels?
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Initial segment or axon hillock
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Where in the neuron is an action potential initially generated?
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Voltage-gated Na+ channels
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Which type of channel has an inactivation phase?
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Voltage-gated K+ channels open more slowly than voltage-gated Na+ channels, even though they are activated at the same time
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What is true about the opening of voltage-gated Na+ and K+ channels
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The membrane potential at the axon hillock must reach a trigger point called threshold potential
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What must happen before an action potential is generated?
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For a given neuron, once the action potential is generated, it maintains the same amplitude and duration as it travels down the axon
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What is meant when we say the action potential is an "all or none" event?
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During the peak of depolarization
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During the action potential, when does sodium permeability initially decrease?
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The repolarization phase
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The rapid decrease in sodium permeability and simultaneous increase in potassium permeability is responsible for
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100 mV
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What is the approximate amplitude of an action potential?
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It is due to K+ and Na+ leakage channels
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What is true about the resting membrane potential (RMP)?
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Na+ is entering the cell
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During the action potential of a neuron, which ion is primarily crossing the membrane during the depolarization phase, and in which direction is the ion moving?
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Na+ channels are inactivating, and K+ channels are opening
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What is happening to voltage gated channels at the peak of an action potential?
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K+ ions leaving the cell through voltage gated channels
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The repolarization phase of the action potential, where voltage becomes more negative after the +30mV peak is caused primarily by
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K+ ions diffusing through voltage-gated channels
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During an action potential, hyperpolarization beyond the RMP is due to
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K+ channels close. Na+ channels go from an inactivated state to a closed state
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During the hyperpolarization phase of the action potential what happens to voltage-gated ion channels
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Na+ ions move into the axon, K+ ions move out
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What is the direction of the ions when their voltage-gated channels open?
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An influx of sodium ions form the current action potential depolarizes the adjacent area
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How is an action potential propagated along an axon?
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The areas that have had the action potential are refractory to a new action potential
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Why does the action potential only move away from the cell body?
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A small myelinated axon
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The velocity of the action potential is fastest in which of the following axons
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Na+
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The diffusion of what ion, across the neuronal membrane is responsible for the local currents that depolarize regions of the axon to the threshold?
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The generation of local currents
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An action potential in one segment of axon causes adjacent sections of axon membrane to reach threshold through what mechanisms?
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The previous axonal segment is in the refractory period
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During AP propagation in an unmyelinated axon, why doesn't the action potential suddenly "double back" and start propagating in the opposite direction
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The nodes are more permeable to ions
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In a myelinated axon, how do the nodes of Ranvier differ from other segments of the same axon?
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At the nodes of Ranvier
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Where are action potentials regenerated as they propagate along a myelinated axon?
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Saltatory conduction
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The node-to node "jumping regeneration of an action potential along a myelinated axon is called
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The speed of action potential propagation would be slower
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If a myelinated neuron was affected by demyelination, how would this affect action potentials in that neuron
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The action potential can only travel one way down the axon
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What is the significance of the refractory period
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It is impossible to generate an action potential in that section of membrane, regardless of the stimulus strength
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During the absolute refractory period
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During this time an exceptionally strong stimulus can trigger a response
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Relative refractory period
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Neuron
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What is an example of a presynaptic cell?
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Chemically gated channels
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Which of the following has a role in the postsynaptic cell during synaptic activity?
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Calcium influx into the synaptic terminal causes vesicle fusion with the presynaptic membrane
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What is the role of calcium in synaptic activity?
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Neurotransmitter binds to receptors on the postsynaptic cell membrane and allows ions to diffuse across the membrane
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What is the role of neurotransmitter at a chemical synapse?
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Exocytosis
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Neurotransmitter is released from presynaptic neurons through what mechanism?
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A chemically gated channel
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What type of channel on the postsynaptic membrane binds neurotransmitters?
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postsynaptic cell
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Excitatory graded potentials fire an action potential from the
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Reuptake, degradation and diffusion
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Mechanisms that terminate neurotransmitter activity
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dendrites
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Graded (synaptic) potentials occur at