Lab 10

25 July 2022
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18 test answers

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question
Do you know when rhesus incompatibility can cause problems?
answer
When maternal and fetal Rhesus status are different
question
Red blood cell count is typically decreased in HDN because...
answer
...the cells are recognized by the antibodies and destroyed
question
If antibodies and antigens can bind together, which statement is true of antigens?
answer
They are molecules capable of triggering an immune reaction
question
How many polypeptide chains build up an antibody?
answer
Four
question
According to the theory, which antibody isotype crosses the placenta?
answer
IgG
question
How much higher is the avidity of IgMeye G M compared to IgGeye G G assumed that both isotypes have the same affinity?
answer
5-fold
question
Which cell type produces antibodies?
answer
B cells
question
What are the four types of bonds in an antibody-antigen complex?
answer
Hydrogen bonds, Van der Waals forces, ionic bonds and hydrophobic interactions
question
What is present in the test circles on the Eldon cards?
answer
Antibodies and one empty circle
question
What do the antibodies in the 'Anti-D' test circle detect?
answer
Rhesus antigen
question
What is the significance of having a control?
answer
To ensure that the test card is working correctly
question
What happened when the blood agglutinated?
answer
The antibodies formed a complex with antigens on the surface of red blood cells
question
Why can agglutination be lethal for the patient when it occurs during a blood transfusion?
answer
Agglutination can cause blockages in the patient's blood vessels
question
We just received blood from a donor with a B-be negative blood type. Could any of the patients we've just typed receive blood from this donor?
answer
Yes, patient 2 and patient 4
question
Why is blood type O-negative called the 'universal donor'?
answer
There are no antigens on the red blood cells that can be recognized as foreign
question
What does HDN mean?
answer
Hemolytic Disease of the Newborn
question
Can you determine if there is a Rhesus incompatibility between Carmen and her second child?
answer
Yes, there is a Rhesus incompatibility
question
Have you noticed that Carmen and her first child don't have compatible ABOA B O blood groups? Why does an ABOA B O incompatibility between a mother and her child rarely causes severe problems?
answer
Typically IgM is raised against A and B antigen, which can't cross the placenta