RNA molecules that do not encode polypeptides are called ...... - ....... RNAs.
answer
non coding
question
In this image, an ncRNA is shown bound to what type of molecule?
Multiple choice question.
mRNA
Protein
DNA
Small molecule
answer
mRNA
question
Match each ncRNA function to its correct description
Scaffold
answer
Some ncRNAs contain binding sites for multiple molecules
question
Match each ncRNA function to its correct description
Guide
answer
Some ncRNAs function to deliver a molecule to a specific site
question
Match each ncRNA function to its correct description
Ribozyme
answer
Some ncRNAs have catalytic function
question
Match each ncRNA function to its correct description
Blocker
answer
Some ncRNAs prevent cellular processes from occurring
question
Match each ncRNA function to its correct description
Decoy
answer
Some ncRNAs bind to other ncRNAs and sequester them
question
ncRNAs that contain binding sites for multiple components can act as a(n) ...... for the formation of a complex.
answer
scaffold
question
An ncRNA that binds to a protein and brings it to a specific site in the cell's DNA is performing what function?
Multiple choice question.
Blocker
Scaffold
Guide
Ribozyme
answer
Guide
question
Non-coding RNAs are ______.
Multiple choice question.
short RNA molecules
RNA molecules that do not encode polypeptides
mRNA molecules that are not translated
answer
RNA molecules that do not encode polypeptides
question
Select the molecules to which ncRNAs commonly bind.
Multiple select question.
Proteins
Small molecules
mRNA
Lipids
DNA
Carbohydrates
answer
Proteins
Small molecules
mRNA
DNA
question
Select functions commonly carried out by ncRNAs.
answer
Guide
Ribozyme
Decoy
Alteration of protein function or stability
Scaffold
Blocker
question
In this figure, what role is played by the ncRNA?
Multiple choice question.
Scaffold
Decoy
Blocker
Ribozyme
answer
Scaffold
question
The ncRNA shown is helping a protein find a specific location on this DNA molecule. The ncRNA is acting as a ______.
Multiple choice question.
decoy
blocker
guide
scaffold
answer
guide
question
When an ncRNA binds to a(n) ....... , it can alter its ability to act as a catalyst, or its ability to bind to another molecule.
answer
protein
question
Select ways in which the binding of an ncRNA to a protein may affect the protein's function.
Multiple select question.
It may affect the ability of the protein to act as a catalyst.
It may affect the sequence of the protein.
It may affect the ability of the protein to bind another molecule.
It may affect the stability of the protein.
answer
It may affect the ability of the protein to act as a catalyst.
It may affect the ability of the protein to bind another molecule.
It may affect the stability of the protein.
question
Which ncRNA associates with proteins to direct the synthesis of certain polypeptides to the plasma membrane?
Multiple choice question.
HOTAIR
SRP RNA
snRNA
snoRNA
answer
SRP RNA
question
Select the molecules to which ncRNAs commonly bind.
Multiple select question.
Proteins
Lipids
Carbohydrates
Small molecules
DNA
mRNA
answer
Proteins
Small molecules
DNA
mRNA
question
A precursor to living cells consisting of an aggregate of molecules and macromolecules that acquired a boundary is called a(n) ......
answer
protobiont
question
Key features of ...... that made them possible precursors of living cells include a boundary separating their contents from the external environment, polymers containing information, and polymers with catalytic functions.
answer
protobionts
question
Match the ncRNA with its function.
TERC
answer
Facilitates the binding of telomerase to the telomere
Match the ncRNA with its function.
PIWI-interacting RNA
answer
Prevents the movement of transposable elements
question
A period on earth when RNA molecules, but not DNA or proteins, were found within protobionts is known as the ...... ......
answer
RNA world
question
What is a protobiont?
Multiple choice question.
A type of ncRNA
A precursor to living cells
A type of therapy involving ncRNAs
A protein required for miRNA processing
answer
A precursor to living cells
question
Select features that make protobionts possible precursors of living cells.
answer
Polymers inside the protobiont had catalytic functions.
Polymers inside the protobiont contained information.
A boundary separated the internal contents of the protobiont from the external environment.
Protobionts developed the capability of self-replication.
question
Select key functions carried out by RNA in an RNA world.
Multiple select question.
Catalytic function
The ability to store information in its nucleotide base sequence
Ability to form organelles
Ability to serve as a transcript for DNA in the protobiont
The capacity for self-replication
answer
Catalytic function
The ability to store information in its nucleotide base sequence
The capacity for self-replication
question
The first macromolecule found in protobionts is thought to be ______.
Multiple choice question.
RNA
DNA
protein
answer
RNA
question
RNA's ability to work as a ______ would be crucial in its self-replication role in an RNA world.
Multiple choice question.
guide
blocker
scaffold
ribozyme
answer
ribozyme
question
Following the RNA world, which role did DNA take over from RNA?
Multiple choice question.
Synthesis of proteins
Long-term storage of information
Catalysis of chemical reactions
answer
Long-term storage of information
question
What new functions would early cells have experienced by the introduction of proteins?
Multiple select question.
Structural roles of proteins
Greater self-replicative ability than RNA
Greater catalytic ability than RNA
Uptake of substances into living cells by membrane proteins
answer
Structural roles of proteins
Greater catalytic ability than RNA
Uptake of substances into living cells by membrane proteins
question
Select the roles played by the ncRNA HOTAIR.
Multiple select question.
Direct binding to mRNAs to block translation
Activation of gene transcription
Repression of gene transcription
Alteration of chromatin structure
answer
Repression of gene transcription
Alteration of chromatin structure
question
Select advantages of having both DNA and RNA in cells versus RNA alone.
Multiple select question.
RNA would be free to perform other functions.
DNA is more complex than RNA.
DNA is more stable than RNA.
DNA could relieve RNA of its long-term storage role.
answer
RNA would be free to perform other functions.
DNA is more stable than RNA.
DNA could relieve RNA of its long-term storage role.
question
The first macromolecule found in protobionts is thought to be ______.
Multiple choice question.
protein
DNA
RNA
answer
RNA
question
What is the function of the ncRNA HOTAIR?
Multiple choice question.
Decoy
Blocker
Ribozyme
Scaffold
answer
Scaffold
question
Rank these molecules according to catalytic activity, placing the molecule with the greatest catalytic ability on top.
answer
1. Proteins
2. RNA
3.DNA
question
The ncRNA Hox transcript antisense intergenic RNA is also known as .......
answer
HOTAIR
question
HOTAIR binds to a region near a target gene that ______.
Multiple choice question.
contains many purines
contains many pyrimidines
contains mainly As and Ts
contains mainly Gs and Cs
answer
contains many purines
question
Following the RNA world, which role did DNA take over from RNA?
Multiple choice question.
Synthesis of proteins
Catalysis of chemical reactions
Long-term storage of information
answer
Long-term storage of information
question
What type of molecules does HOTAIR help guide to their target genes?
Multiple choice question.
Histone-modifying complexes
Kinases
Ubiquitin ligases
Endonucleases
DNA-modifying complexes
answer
Histone-modifying complexes
question
How does a HOTAIR complex bind to target genes?
answer
A portion of HOTAIR is complementary to a GA-rich region found near target genes.
question
Select advantages of having both DNA and RNA in cells versus RNA alone.
Multiple select question.
DNA could relieve RNA of its long-term storage role.
DNA is more stable than RNA.
RNA would be free to perform other functions.
DNA is more complex than RNA.
answer
DNA could relieve RNA of its long-term storage role.
DNA is more stable than RNA.
RNA would be free to perform other functions.
question
What is the function of the ncRNA HOTAIR?
Multiple choice question.
Ribozyme
Blocker
Decoy
Scaffold
answer
Scaffold
question
Identify the roles of the protein LSD1 in the repression of transcription by HOTAIR.
Multiple select question.
Binds to 3' end of HOTAIR
Binds to 5' end of HOTAIR
Demethylates H3K27
Demethylates H3K4
Trimethylates H3K27
answer
Binds to 3' end of HOTAIR
Demethylates H3K4
question
The ncRNA Hox transcript antisense intergenic RNA is also known as .....
answer
HOTAIR
question
HOTAIR binds to a region near a target gene that ______.
Multiple choice question.
contains mainly As and Ts
contains many pyrimidines
contains mainly Gs and Cs
contains many purines
answer
contains many purines
question
Why was C. elegans used as the experimental organism in experiments carried out by Mello and Fire?
answer
It is relatively easy to inject with RNA.
Expression of many of its genes had already been established.
question
Identify the roles of the PCR2 complex in the repression of transcription by HOTAIR.
answer
Trimethylates H3K27
Binds to 5' end of HOTAIR
question
This figure shows the outcome of the in situ hybridization procedure measuring mex-3 mRNA carried out by Mello and Fire. Match each letter with the correct experimental treatment.
Instructions
answer
A- Control
B- Injected with mex-3 antisense RNA
C- Injected with double-stranded RNA
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