Creatine Phosphate

25 July 2022
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Creatine Phosphate
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a high energy phosphate; acts as a reservoir of phosphate to donate to ADP; stored in muscles along edges of I-band; consumed in meat or synthesized in liver, kidneys and pancreas
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Creatine
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a protein/amine
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Creatine Phosphate system
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CrP+ADP---Creatine Kinase----> ATP+Creatine
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Important characteristics
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1 step chemical reaction, very fast, catalyzed by creatine kinase, 1 CrP molecule rephosphorylates 1 ATP, anaerobic energy system, Lasts about 10 seconds with high intensity exercise, replenishes in 1-2 mins, CrP depletion associated with muscle fatigue, predominant energy system used for short-term, very high intensity exercise
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CrP & Fatigue
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During high intensity exercise, ATP concentrations kept high b/c it is rephosphorylated rapidly by CrP; Once CrP is depleted and ATP concentration falls to ~70% ATP usage slows down - force production reduced & muscle fatigue occurs
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ATP, Creatine Utilization
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Exercising at the highest voluntary intensity doesn't decline ATP that much; percentage goes down but total concentration doesn't go down; study shows that this supports that ATP must be replenished rapidly
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Rephosphorylation of Crp
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Restoration of CrP store from Creatin occurs aerobically; some of the ATP produced in the mitochondria (aerobically) can be used to rephosphorylate Crp from Cr thru the Creatine shuttle
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The Creatine Shuttle
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When creatine shuttles down to mitochondria and is rephosphorylated by ATP from mitochondria; process occurs during recovery
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Creatine Kinase
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enzyme that catalyzes the CrP energy system; found in body in 3 isoforms; present in sarcoplasm and mitochondria; can change rate of catalyzing - fast twitch fibers have high CK b/c need large amounts of energy quickly
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Isoenzymes of CK
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CK-BB - found mostly in brain tissue, CK-MM - found mostly in skeletal muscle tissue, CK-MB - found mostly in heart muscle